Distinct binding modes of vinculin isoforms underlie their functional differences

Vinculin and its splice isoform metavinculin play key roles in regulating cellular morphology, motility and force transduction. Vinculin is distinct from metavinculin in its ability to bundle filamentous actin (F-actin). To elucidate the molecular basis for these differences, we employed computation...

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Gepubliceerd in:Structure
Hoofdauteurs: Krokhotin, Andrey, Sarker, Muzaddid, Sevilla, Ernesto Alva, Costantini, Lindsey M., Griffith, Jack, Campbell, Sharon L., Dokholyan, Nikolay V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774862/
https://ncbi.nlm.nih.gov/pubmed/31422909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.07.013
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