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The cytoplasmic DNA sensor cGAS promotes mitotic cell death
Pathogenic and other cytoplasmic DNAs activate the cGAS-STING pathway to induce inflammation via transcriptional activation by IRF3 and NFκB, but the functional consequences of exposing cGAS to chromosomes upon mitotic nuclear envelope breakdown are unknown. Here we show that nucleosomes competitive...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693521/ https://ncbi.nlm.nih.gov/pubmed/31299200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.05.035 |
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