27-Hydroxycholesterol Is an Estrogen Receptor β–Selective Negative Allosteric Modifier of 17β-Estradiol Binding

Estrogens bind to two nuclear estrogen receptor (ER) subtypes, ERα and ERβ, which are expressed in differing amounts in various tissues. The endogenous estrogen, 17β-estradiol (E2), binds to both subtypes with nearly equal affinity and is the prototypical agonist. Selective estrogen receptor modulat...

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Dettagli Bibliografici
Pubblicato in:Endocrinology
Autori principali: Starkey, Nicholas J E, Li, Yufei, Drenkhahn-Weinaug, Sara K, Liu, Jinghua, Lubahn, Dennis B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693046/
https://ncbi.nlm.nih.gov/pubmed/29579190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2018-00081
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