The Endogenous Selective Estrogen Receptor Modulator 27-Hydroxycholesterol Is a Negative Regulator of Bone Homeostasis

Osteoporosis is an important clinical problem, affecting more than 50% of people over age 50 yr. Estrogen signaling is critical for maintaining proper bone density, and the identification of an endogenous selective estrogen receptor (ER) modulator, 27-hydroxycholesterol (27HC), suggests a mechanism...

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Main Authors: DuSell, Carolyn D., Nelson, Erik R., Wang, Xiaojuan, Abdo, Jennifer, Mödder, Ulrike I., Umetani, Michihisa, Gesty-Palmer, Diane, Javitt, Norman B., Khosla, Sundeep, McDonnell, Donald P.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940523/
https://ncbi.nlm.nih.gov/pubmed/20501668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0080
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