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Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold
Attempts to create novel ligand-binding proteins often focus on formation of a binding pocket with shape complementarity against the desired ligand (particularly for compounds that lack distinct polar moieties). Although designed proteins often exhibit binding of the desired ligand, in some cases th...
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| Pubblicato in: | Protein Eng Des Sel |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692866/ https://ncbi.nlm.nih.gov/pubmed/30566669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy031 |
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