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Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold
Attempts to create novel ligand-binding proteins often focus on formation of a binding pocket with shape complementarity against the desired ligand (particularly for compounds that lack distinct polar moieties). Although designed proteins often exhibit binding of the desired ligand, in some cases th...
Uloženo v:
| Vydáno v: | Protein Eng Des Sel |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692866/ https://ncbi.nlm.nih.gov/pubmed/30566669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy031 |
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