Computational Design of Ligand Binding Proteins with High Affinity and Selectivity

The ability to design proteins with high affinity and selectivity for any given small molecule would have numerous applications in biosensing, diagnostics, and therapeutics, and is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition phenomena. Atte...

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Bibliografiske detaljer
Main Authors: Tinberg, Christine E., Khare, Sagar D., Dou, Jiayi, Doyle, Lindsey, Nelson, Jorgen W., Schena, Alberto, Jankowski, Wojciech, Kalodimos, Charalampos G., Johnsson, Kai, Stoddard, Barry L., Baker, David
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898436/
https://ncbi.nlm.nih.gov/pubmed/24005320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12443
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