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Modulating protein activity using tethered ligands with mutually exclusive binding sites

The possibility to design proteins whose activities can be switched on and off by unrelated effector molecules would enable applications in various research areas, ranging from biosensing to synthetic biology. We describe here a general method to modulate the activity of a protein in response to the...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Schena, Alberto, Griss, Rudolf, Johnsson, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525150/
https://ncbi.nlm.nih.gov/pubmed/26198003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8830
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