Spermidine‐enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK/mTOR signalling pathway

BACKGROUND AND PURPOSE: Spermidine, a natural polyamine, is abundant in mammalian cells and is involved in cell growth, proliferation, and regeneration. Recently, oral spermidine supplements were cardioprotective in age‐related cardiac dysfunction, through enhancing autophagic flux. However, the eff...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Yan, Jing, Yan, Jian‐Yun, Wang, Yu‐Xi, Ling, Yuan‐Na, Song, Xu‐Dong, Wang, Si‐Yi, Liu, Hai‐Qiong, Liu, Qi‐Cai, Zhang, Ya, Yang, Ping‐Zhen, Wang, Xian‐Bao, Chen, Ai‐Hua
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692641/
https://ncbi.nlm.nih.gov/pubmed/31077347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14706
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