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The distribution of fitness effects among synonymous mutations in a gene under directional selection
The fitness effects of synonymous mutations, nucleotide changes that do not alter the encoded amino acid, have often been assumed to be neutral, but a growing body of evidence suggests otherwise. We used site-directed mutagenesis coupled with direct measures of competitive fitness to estimate the di...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692132/ https://ncbi.nlm.nih.gov/pubmed/31322500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45952 |
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