Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)‑7-Hydroxy‑N‑[(1S)‑2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structure—activity relationship (SAR) study of a recently discovered new class...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Ondachi, Pauline W., Kormos, Chad M., Runyon, Scott P., Thomas, James B., Mascarella, S. Wayne, Decker, Ann M., Navarro, Hernán A, Fennell, Timothy R., Snyder, Rodney W., Carroll, F. Ivy
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692079/
https://ncbi.nlm.nih.gov/pubmed/30117738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00673
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