Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)-N-[1R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic)

Animal pharmacological studies suggest that potent and selective κ opioid receptor antagonists have potential as pharmacotherapies targeting depression, anxiety, and substance abuse (opiates, alcohol, nicotine, cocaine). We recently reported lead compound 1 as a new class of κ opioid receptor antago...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Kormos, Chad M., Ondachi, Pauline W., Runyon, Scott P., Thomas, James B., Mascarella, S. Wayne, Decker, Ann M., Navarro, Hernań A, Fennell, Timothy R., Snyder, Rodney W., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692071/
https://ncbi.nlm.nih.gov/pubmed/30032602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00674
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