The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

There is a high unmet need for developing treatments for nonalcoholic fatty liver disease (NAFLD), for which there are no approved drugs today. Here, we used a human in vitro disease model to understand mechanisms linked to genetic risk variants associated with NAFLD. The model is based on 3D sphero...

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Publicado no:Sci Rep
Main Authors: Prill, Sebastian, Caddeo, Andrea, Baselli, Guido, Jamialahmadi, Oveis, Dongiovanni, Paola, Rametta, Raffaela, Kanebratt, Kajsa P., Pujia, Arturo, Pingitore, Piero, Mancina, Rosellina Margherita, Lindén, Daniel, Whatling, Carl, Janefeldt, Annika, Kozyra, Mikael, Ingelman-Sundberg, Magnus, Valenti, Luca, Andersson, Tommy B., Romeo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690969/
https://ncbi.nlm.nih.gov/pubmed/31406127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47737-w
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