The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1

Apolipoprotein B mRNA editing enzyme catalytic subunit-like protein 3B (APOBEC3B or A3B), as other APOBEC3 members, is a single-stranded (ss)DNA cytosine deaminase with antiviral activity. A3B is also overexpressed in multiple tumor types, such as carcinomas of the bladder, cervix, lung, head/neck,...

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Vydáno v:J Biol Chem
Hlavní autoři: McCann, Jennifer L., Klein, Madeline M., Leland, Evelyn M., Law, Emily K., Brown, William L., Salamango, Daniel J., Harris, Reuben S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690700/
https://ncbi.nlm.nih.gov/pubmed/31217276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008443
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