Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice

Conjugated equine estrogens (CEEs), whose brand name is Premarin, are widely used as a hormone-replacement therapy (HRT) drug to manage postmenopausal symptoms in women. Extracted from pregnant mare urine, CEEs are composed of nearly a dozen estrogens existing in an inactive sulfated form. To determ...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Feng, Ye, Xie, Yang, Xu, Meishu, Li, Linhao, Selcer, Kyle W., Oberly, Patrick J., Poloyac, Samuel M., Wang, Hongbing, Li, Chengjiang, Dong, Fengqin, Yu, Chaohui, Xie, Wen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690699/
https://ncbi.nlm.nih.gov/pubmed/31217279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009181
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