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Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice

Conjugated equine estrogens (CEEs), whose brand name is Premarin, are widely used as a hormone-replacement therapy (HRT) drug to manage postmenopausal symptoms in women. Extracted from pregnant mare urine, CEEs are composed of nearly a dozen estrogens existing in an inactive sulfated form. To determ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Feng, Ye, Xie, Yang, Xu, Meishu, Li, Linhao, Selcer, Kyle W., Oberly, Patrick J., Poloyac, Samuel M., Wang, Hongbing, Li, Chengjiang, Dong, Fengqin, Yu, Chaohui, Xie, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690699/
https://ncbi.nlm.nih.gov/pubmed/31217279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009181
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