Hepatic Overexpression of Steroid Sulfatase Ameliorates Mouse Models of Obesity and Type 2 Diabetes through Sex-specific Mechanisms

The steroid sulfatase (STS)-mediated desulfation is a critical metabolic mechanism that regulates the chemical and functional homeostasis of endogenous and exogenous molecules. In this report, we first showed that the liver expression of Sts was induced in both the high fat diet (HFD) and ob/ob mode...

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Detalhes bibliográficos
Main Authors: Jiang, Mengxi, He, Jinhan, Kucera, Heidi, Gaikwad, Nilesh W., Zhang, Bin, Xu, Meishu, O'Doherty, Robert M., Selcer, Kyle W., Xie, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961640/
https://ncbi.nlm.nih.gov/pubmed/24497646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535914
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