Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice

Conjugated equine estrogens (CEEs), whose brand name is Premarin, are widely used as a hormone-replacement therapy (HRT) drug to manage postmenopausal symptoms in women. Extracted from pregnant mare urine, CEEs are composed of nearly a dozen estrogens existing in an inactive sulfated form. To determ...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Feng, Ye, Xie, Yang, Xu, Meishu, Li, Linhao, Selcer, Kyle W., Oberly, Patrick J., Poloyac, Samuel M., Wang, Hongbing, Li, Chengjiang, Dong, Fengqin, Yu, Chaohui, Xie, Wen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690699/
https://ncbi.nlm.nih.gov/pubmed/31217279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009181
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