High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay

Phosphatidylserine decarboxylases (PSDs) catalyze the decarboxylation of phosphatidylserine to generate phosphatidylethanolamine, a critical step in phospholipid metabolism in both prokaryotes and eukaryotes. Most PSDs are membrane-bound, and classical radioisotope-based assays for determining their...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hendricson, Adam, Umlauf, Sheila, Choi, Jae-Yeon, Thekkiniath, Jose, Surovtseva, Yulia V., Fuller, Kevin K., Reynolds, Todd B., Voelker, Dennis R., Ben Mamoun, Choukri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Methods and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690695/
https://ncbi.nlm.nih.gov/pubmed/31227523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007766
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