Antibody–Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome–Disruptive Peptide

[Image: see text] Antibody–drug conjugates are an important class of cancer therapeutics. These agents generally bind a specific cell surface receptor, undergo receptor-mediated endocytosis, and enter the endosomal–lysosomal system, where the environment in these organelles facilitates the release o...

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Veröffentlicht in:ACS Omega
Hauptverfasser: Knewtson, Kelsey E., Perera, Chamani, Hymel, David, Gao, Zhe, Lee, Molly M., Peterson, Blake R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690568/
https://ncbi.nlm.nih.gov/pubmed/31460422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01585
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