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Cellular Uptake and Cytotoxicity of Drug-Peptide Conjugates Regulated by Conjugation Site
Conjugation of anticancer drugs to hydrophilic peptides such as Tat is a widely adopted strategy to improve the drug’s solubility, cellular uptake and potency against cancerous cells. Here we report that attachment of an anticancer drug doxorubicin to the N- or C-terminal of the Tat peptide can have...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651882/ https://ncbi.nlm.nih.gov/pubmed/23514455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc300585h |
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