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Natural Product MDM2 Inhibitors: Anticancer Activity and Mechanisms of Action

The mdm2 oncogene has recently been suggested to be a valuable target for cancer therapy and prevention. Overexpression of mdm2 is often seen in various human cancers and correlates with high-grade, late-stage, and more treatment-resistant tumors. The MDM2-p53 auto-regulatory loop has been extensive...

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Dettagli Bibliografici
Pubblicato in:Curr Med Chem
Autori principali: Qin, J.-J., Nag, S., Voruganti, S., Wang, W., Zhang, R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690201/
https://ncbi.nlm.nih.gov/pubmed/22830335
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