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UBC9 mutant reveals the impact of protein dynamics on substrate selectivity and SUMO chain linkages
SUMO, a conserved ubiquitin-like protein, is conjugated to a multitude of cellular proteins to maintain genomic integrity and resist genotoxic stress. Studies of the SUMO E2 conjugating enzyme mutant, UBC9(P123L), suggested that altered substrate specificity enhances cell sensitivity to DNA damaging...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690184/ https://ncbi.nlm.nih.gov/pubmed/30574775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01045 |
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