Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation

Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) regulate many cellular processes, including genome integrity, gene expression, and ribosome biogenesis. The E2-conjugating enzyme Ubc9 catalyzes the conjugation of SUMOs to ϵ-amino groups of lysine residues in target proteins....

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Publicat a:J Biol Chem
Autors principals: Wiechmann, Svenja, Gärtner, Anne, Kniss, Andreas, Stengl, Andreas, Behrends, Christian, Rogov, Vladimir V., Rodriguez, Manuel S., Dötsch, Volker, Müller, Stefan, Ernst, Andreas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602394/
https://ncbi.nlm.nih.gov/pubmed/28784659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794255
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