UBC9 mutant reveals the impact of protein dynamics on substrate selectivity and SUMO chain linkages

SUMO, a conserved ubiquitin-like protein, is conjugated to a multitude of cellular proteins to maintain genomic integrity and resist genotoxic stress. Studies of the SUMO E2 conjugating enzyme mutant, UBC9(P123L), suggested that altered substrate specificity enhances cell sensitivity to DNA damaging...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Wright, Christine M., Whitaker, Robert H., Onuiri, Joshua E., Blackburn, Tessa, McGarity, Sierra, Bjornsti, Mary-Ann, Placzek, William J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690184/
https://ncbi.nlm.nih.gov/pubmed/30574775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01045
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller