Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer

Platinum-based chemotherapy is recommended as the first-line treatment regimen for patients with advanced non-small-cell lung cancer (NSCLC). Lobaplatin (LBP), a third-generation platinum anti-neoplastic agent, has shown an improved efficacy. This study is aimed to investigate the mechanisms of LBP-...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Zhang, Hongming, Chen, Runzhe, Wang, Xiyong, Zhang, Haijun, Zhu, Xiaoli, Chen, Jibei
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689983/
https://ncbi.nlm.nih.gov/pubmed/31428569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00538
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