Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope

The proapoptotic activity of the transcription factor p53 critically depends on the phosphorylation of serine 46 (p53S46P). Here, we show that syncytia containing p53S46P could be detected in lymph node biopsies from human immunodeficiency virus (HIV)-1 carriers, in the brain of patients with HIV-1–...

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Main Authors: Perfettini, Jean-Luc, Castedo, Maria, Nardacci, Roberta, Ciccosanti, Fabiola, Boya, Patricia, Roumier, Thomas, Larochette, Nathanael, Piacentini, Mauro, Kroemer, Guido
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212781/
https://ncbi.nlm.nih.gov/pubmed/15642743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041502
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