NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope

The coculture of cells expressing the HIV-1 envelope glycoprotein complex (Env) with cells expressing CD4 results into cell fusion, deregulated mitosis, and subsequent cell death. Here, we show that NF-κB, p53, and AP1 are activated in Env-elicited apoptosis. The nuclear factor κB (NF-κB) super repr...

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Main Authors: Perfettini, Jean-Luc, Roumier, Thomas, Castedo, Maria, Larochette, Nathanael, Boya, Patricia, Raynal, Brigitte, Lazar, Vladimir, Ciccosanti, Fabiola, Nardacci, Roberta, Penninger, Josef, Piacentini, Mauro, Kroemer, Guido
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213296/
https://ncbi.nlm.nih.gov/pubmed/14993250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031216
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