Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro α-glucosidase inhibition

PURPOSE: We aimed to enhance the solubility, dissolution rate, oral bioavailability, and α-glucosidase inhibition of glimepiride (Glm) by fabricating its nanosuspension using a precipitation–ultrasonication approach. METHODS: Glm nanosuspensions were fabricated using optimized processing conditions....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Int J Nanomedicine
Päätekijät: Rahim, Haroon, Sadiq, Abdul, Khan, Shahzeb, Amin, Fazli, Ullah, Riaz, Shahat, Abdelaaty A, Mahmood, Hafiz Majid
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Dove 2019
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689535/
https://ncbi.nlm.nih.gov/pubmed/31496686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S210548
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