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Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro α-glucosidase inhibition
PURPOSE: We aimed to enhance the solubility, dissolution rate, oral bioavailability, and α-glucosidase inhibition of glimepiride (Glm) by fabricating its nanosuspension using a precipitation–ultrasonication approach. METHODS: Glm nanosuspensions were fabricated using optimized processing conditions....
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| Udgivet i: | Int J Nanomedicine |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Dove
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6689535/ https://ncbi.nlm.nih.gov/pubmed/31496686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S210548 |
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