The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range

The molecular chaperone Hsp90 is an important regulator of proteostasis. It has remained unclear why S. cerevisiae possesses two Hsp90 isoforms, the constitutively expressed Hsc82 and the stress-inducible Hsp82. Here, we report distinct differences despite a sequence identity of 97%. Consistent with...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Girstmair, Hannah, Tippel, Franziska, Lopez, Abraham, Tych, Katarzyna, Stein, Frank, Haberkant, Per, Schmid, Philipp Werner Norbert, Helm, Dominic, Rief, Matthias, Sattler, Michael, Buchner, Johannes
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689086/
https://ncbi.nlm.nih.gov/pubmed/31399574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11518-w
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