PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

mRNA modifications play important roles in regulating gene expression. One of the abundant mRNA modifications is N6,2-O-dimethyladenosine (m6Am). Here, we demonstrate that m6Am is an evolutionarily conserved mRNA modification mediated by the Phosphorylated CTD Interacting Factor 1 (PCIF1), which cat...

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Publicado no:Mol Cell
Main Authors: Sendinc, Erdem, Valle-Garcia, David, Dhall, Abhinav, Chen, Hao, Henriques, Telmo, Navarrete-Perea, Jose, Sheng, Wanqiang, Gygi, Steven P., Adelman, Karen, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688901/
https://ncbi.nlm.nih.gov/pubmed/31279659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.030
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