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Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β

Interferons induce cell-intrinsic responses associated with resistance to viral infection. To overcome the suppressive action of interferons and their effectors, viruses have evolved diverse mechanisms. Using vesicular stomatitis virus (VSV), we report that the host cell N6-adenosine messenger RNA (...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tartell, Michael A., Boulias, Konstantinos, Hoffmann, Gabriela Brunsting, Bloyet, Louis-Marie, Greer, Eric Lieberman, Whelan, Sean P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307471/
https://ncbi.nlm.nih.gov/pubmed/34266951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025769118
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