Co-crystal structure of the iMango-III fluorescent RNA aptamer using an X-ray free-electron laser

Turn-on aptamers are in vitro-selected RNAs that bind to conditionally fluorescent small molecules and enhance their fluorescence. Upon binding TO1-biotin, the iMango-III aptamer achieves the largest fluorescence enhancement reported for turn-on aptamers (over 5000-fold). This aptamer was generated...

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Détails bibliographiques
Publié dans:Acta Crystallogr F Struct Biol Commun
Auteurs principaux: Trachman, Robert J., Stagno, Jason R., Conrad, Chelsie, Jones, Christopher P., Fischer, Pontus, Meents, Alke, Wang, Yun-Xing, Ferré-D’Amaré, Adrian R.
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2019
Sujets:
Research Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688663/
https://ncbi.nlm.nih.gov/pubmed/31397326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19010136
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