Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor suppressor, but in advanced metastatic disease it swi...

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Dades bibliogràfiques
Publicat a:Front Oncol
Autors principals: Pollard, Bette S., Suckow, Mark. A., Wolter, William R., Starr, Joshua M., Eidelman, Ofer, Dalgard, Clifton L., Kumar, Parameet, Battacharyya, Sharmistha, Srivastava, Meera, Biswas, Roopa, Wilkerson, Matthew D., Zhang, Xijun, Yang, Qingfeng, Pollard, Harvey B.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687970/
https://ncbi.nlm.nih.gov/pubmed/31428571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00630
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