Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor suppressor, but in advanced metastatic disease it swi...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Pollard, Bette S., Suckow, Mark. A., Wolter, William R., Starr, Joshua M., Eidelman, Ofer, Dalgard, Clifton L., Kumar, Parameet, Battacharyya, Sharmistha, Srivastava, Meera, Biswas, Roopa, Wilkerson, Matthew D., Zhang, Xijun, Yang, Qingfeng, Pollard, Harvey B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687970/
https://ncbi.nlm.nih.gov/pubmed/31428571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00630
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