Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that these molecular chaperones recognize a region of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Eftekharzadeh, Bahareh, Banduseela, Varuna C., Chiesa, Giulio, Martínez-Cristóbal, Paula, Rauch, Jennifer N., Nath, Samir R., Schwarz, Daniel M. C., Shao, Hao, Marin-Argany, Marta, Di Sanza, Claudio, Giorgetti, Elisa, Yu, Zhigang, Pierattelli, Roberta, Felli, Isabella C., Brun-Heath, Isabelle, García, Jesús, Nebreda, Ángel R., Gestwicki, Jason E., Lieberman, Andrew P., Salvatella, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687723/
https://ncbi.nlm.nih.gov/pubmed/31395886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11594-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados