Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice

Aging is a significant risk factor for impaired tissue functions and chronic diseases. Age-associated decline in systemic NAD(+) availability plays a critical role in regulating the aging process across many species. Here we show that the circulating levels of extracellular nicotinamide phosphoribos...

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Udgivet i:Cell Metab
Main Authors: Yoshida, Mitsukuni, Satoh, Akiko, Lin, Jonathan B., Mills, Kathryn F., Sasaki, Yo, Rensing, Nicholas, Wong, Michael, Apte, Rajendra S., Imai, Shin-ichiro
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687560/
https://ncbi.nlm.nih.gov/pubmed/31204283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.05.015
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