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A Conserved Allosteric Pathway in Tyrosine Kinase Regulation
An autoinhibitory network of hydrogen bonds located at the kinase hinge (referred to as the ‘molecular brake’) regulates the activity of several receptor tyrosine kinases. The mechanism whereby mutational disengagement of the brake allosterically activates the kinase in human disease is incompletely...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6687525/ https://ncbi.nlm.nih.gov/pubmed/31204250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.05.002 |
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