Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels

TRPM2 is a Ca(2+)-permeable, nonselective cation channel that plays a role in oxidant-induced cell death, insulin secretion, and cytokine release. Few TRPM2 inhibitors have been reported, which hampers the validation of TRPM2 as a drug target. While screening our in-house marine-derived chemical lib...

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Detalhes bibliográficos
Publicado no:J Nat Prod
Main Authors: Starkus, John G., Poerzgen, Peter, Layugan, Kristine, Kawabata, Kelly Galbraith, Goto, Jun-Ichi, Suzuki, Sayuri, Myers, George, Kelly, Michelle, Penner, Reinhold, Fleig, Andrea, Horgen, F. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687308/
https://ncbi.nlm.nih.gov/pubmed/29019677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.7b00515
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