Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans

Anthracyclines cause progressive cardiotoxicity whose ultimate severity is individual to the patient. Genetic determinants contributing to this variation are difficult to study using current mouse models. Our objective was to determine whether a spectrum of anthracycline induced cardiac disease can...

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Vydáno v:G3 (Bethesda)
Hlavní autoři: Zeiss, Caroline J., Gatti, Daniel M., Toro-Salazar, Olga, Davis, Crystal, Lutz, Cathleen M., Spinale, Francis, Stearns, Timothy, Furtado, Milena B., Churchill, Gary A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2019
Témata:
Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686936/
https://ncbi.nlm.nih.gov/pubmed/31263061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.119.400232
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