Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans

Anthracyclines cause progressive cardiotoxicity whose ultimate severity is individual to the patient. Genetic determinants contributing to this variation are difficult to study using current mouse models. Our objective was to determine whether a spectrum of anthracycline induced cardiac disease can...

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發表在:G3 (Bethesda)
Main Authors: Zeiss, Caroline J., Gatti, Daniel M., Toro-Salazar, Olga, Davis, Crystal, Lutz, Cathleen M., Spinale, Francis, Stearns, Timothy, Furtado, Milena B., Churchill, Gary A.
格式: Artigo
語言:Inglês
出版: Genetics Society of America 2019
主題:
Investigations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686936/
https://ncbi.nlm.nih.gov/pubmed/31263061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.119.400232
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