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HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms

BACKGROUND: RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland. Consistent evidence indicates that RUNX2 expression is aberrantly reactivated in cancer and supports tumor progression...

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Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Manzotti, Gloria, Torricelli, Federica, Donati, Benedetta, Sancisi, Valentina, Gugnoni, Mila, Ciarrocchi, Alessia
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686443/
https://ncbi.nlm.nih.gov/pubmed/31395086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1350-5
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