RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN

Aberrant reactivation of embryonic pathways is a common feature of cancer. RUNX2 is a transcription factor crucial during embryogenesis that is aberrantly reactivated in many tumors, including thyroid and breast cancer, where it promotes aggressiveness and metastatic spreading. Currently, the mechan...

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Pubblicato in:Nucleic Acids Res
Autori principali: Sancisi, Valentina, Manzotti, Gloria, Gugnoni, Mila, Rossi, Teresa, Gandolfi, Greta, Gobbi, Giulia, Torricelli, Federica, Catellani, Francesca, Faria do Valle, Italo, Remondini, Daniel, Castellani, Gastone, Ragazzi, Moira, Piana, Simonetta, Ciarrocchi, Alessia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737559/
https://ncbi.nlm.nih.gov/pubmed/28981843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx802
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