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Mapping the Structural Path for Allosteric Inhibition of a Short-Form ATP Phosphoribosyltransferase by Histidine

[Image: see text] ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis, being allosterically inhibited by the final product of the pathway. Allosteric inhibition of long-form ATPPRTs by histidine has been extensively studied, but inhibition of short-form ATPPRTs...

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Vydáno v:Biochemistry
Hlavní autoři: Thomson, Catherine M., Alphey, Magnus S., Fisher, Gemma, da Silva, Rafael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685669/
https://ncbi.nlm.nih.gov/pubmed/31251578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00282
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