Allosteric Activation Shifts the Rate-Limiting Step in a Short-Form ATP Phosphoribosyltransferase

[Image: see text] Short-form ATP phosphoribosyltransferase (ATPPRT) is a hetero-octameric allosteric enzyme comprising four catalytic subunits (HisG(S)) and four regulatory subunits (HisZ). ATPPRT catalyzes the Mg(2+)-dependent condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate (PRPP) to...

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Udgivet i:Biochemistry
Main Authors: Fisher, Gemma, Thomson, Catherine M., Stroek, Rozanne, Czekster, Clarissa M., Hirschi, Jennifer S., da Silva, Rafael G.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128619/
https://ncbi.nlm.nih.gov/pubmed/29940105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00559
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