Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here, we report the identification and characterization in one patien...

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Publicado en:Cancer Immunol Res
Autores principales: Lo, Winifred, Parkhurst, Maria, Robbins, Paul F., Tran, Eric, Lu, Yong-Chen, Jia, Li, Gartner, Jared J., Pasetto, Anna, Deniger, Drew, Malekzadeh, Parisa, Shelton, Thomas E., Prickett, Todd, Ray, Satyajit, Kivitz, Scott, Paria, Biman C., Kriley, Isaac, Schrump, David S., Rosenberg, Steven A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685528/
https://ncbi.nlm.nih.gov/pubmed/30709841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0686
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