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Base editing the mammalian genome
Base editing is a powerful technology that enables programmable conversion of single nucleotides in the mammalian genome. Base editors consist of a partially active Cas9 nuclease (Cas9(D10A)) tethered to a natural or synthetic DNA modifying enzyme. Though only recently described, BE has already show...
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| Publié dans: | Methods |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684841/ https://ncbi.nlm.nih.gov/pubmed/30836137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2019.02.022 |
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