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Base editing the mammalian genome

Base editing is a powerful technology that enables programmable conversion of single nucleotides in the mammalian genome. Base editors consist of a partially active Cas9 nuclease (Cas9(D10A)) tethered to a natural or synthetic DNA modifying enzyme. Though only recently described, BE has already show...

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Bibliografiske detaljer
Udgivet i:Methods
Main Authors: Schatoff, Emma M, Zafra, Maria Paz, Dow, Lukas E
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684841/
https://ncbi.nlm.nih.gov/pubmed/30836137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2019.02.022
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