Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2r(I1565A)) results in partial lethality, overgrowth and intestinal adenoma progression

The cation-independent mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R or IGF2R) traffics IGF2 and M6P ligands between pre-lysosomal and extra-cellular compartments. Specific IGF2 and M6P high-affinity binding occurs via domain-11 and domains-3-5-9, respectively. Mammalian mater...

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Published in:Sci Rep
Main Authors: Hughes, Jennifer, Surakhy, Mirvat, Can, Sermet, Ducker, Martin, Davies, Nick, Szele, Francis, Bühnemann, Claudia, Carter, Emma, Trikin, Roman, Crump, Matthew P., Frago, Susana, Hassan, A. Bassim
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684648/
https://ncbi.nlm.nih.gov/pubmed/31388182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47827-9
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